CD38 and B-cell chronic lymphocytic leukemia: In our setting, BM homing was not specifically blocked using anti-CD38 antibodies (OKT10, data not shown), which were previously shown to antagonize cell adhesion to hyaluronic acid and BM endothelium.[21] Yet, in a recent study, the homing of CLL samples to the BM could be abrogated with a high dose of a different anti-CD38 clone.[9] However, the authors did not analyze whether CD38 expression is needed for entry into the BM.[9] CD38 is a cyclic ADP-ribose that influences calcium signaling[6] and has the propensity to laterally associate with several molecules in membranal lipid rafts [22].