Lines of evidence showed that Ang II could enhance the expression of immediate early gene IEG (c-fos, c-jun, c-myc, etc.), terminal myocardial cell genes (skeleton actin, atrial natriuretic polypeptide), and transforming growth factor β gene in rat myocardial cells, confirming that the upregulation of these genes induces ventricular hypertrophy in the rat model [3]. This evidence concerns the gene AGT and cardiac hypertrophy.