ERBB2 and breast cancer: The ability of curcumin to downregulate EGFR [19, 21, 22] and HER-2 [23] oncoproteins and affect the PI3K/Akt [24] and MAPK [25] pathways, with which herceptin interfered, raised interest in the potential utility of curcumin in the treatment of HER-2-positive breast cancer.