Combination of the thrombospondin-1 peptide ABT-510 with valproic acid was highly effective to regress tumor growth and microvascular density in two different N-Myc-amplified cell lines-derived neuroblastoma xenografts when compared with monotherapy suggesting the potency of combination anti-angiogenic therapy for treatment of neuroblastoma [89]. The gene discussed is MYCN; the disease is neuroblastoma.