A blockade of VEGFR-2 signaling with the selective inhibitor SU1498 or gene silencing with VEGFR-2 siRNA in SB202190 treated cells hindered this prosurvival response and highly induced activation of caspase-3 and caspase-7, indicating that p38 MAPK exerts a negative effect on VEGF-mediated signaling through VEGFR-2 in serum-starved neuroblastoma cells [56]. The gene discussed is KDR; the disease is neuroblastoma.