KDR and neoplasm: ZD6474, a dual tyrosine kinase inhibitor of VEGFR-2 and EGFR, inhibited the phosphorylation of receptor tyrosine kinase in neuroblastoma cells leading to an increase in endothelial cell apoptosis and showed significant anti-tumor activity in seven neuroblastoma cell lines (SK-N-SH, SK-N-SH, SK-NAS, NGP, CHP-134, SH-SY5Y, and SH-EP) [18].