CHKA and neoplasm: The HDACi trichostatin A (TSA), sodium butyrate, and suberoylanilide hydroxamic acid (SAHA) alone and in combination with retinoic acid can increase cyclin kinase inhibitor (CKI) mRNA levels in human neuroblastoma SH-SY5Y cells, and activate CKI promoters to inhibit tumor cell growth in neuroblastoma [67].