Though VEGF is indispensable for neuroblastoma angiogenesis, treatment of neuroblastoma xenograft model with anti-VEGF antibody shows decrease in vascularity and only partial regression of tumor, suggesting that VEGF blockade is not sufficient to prevent neuroblastoma angiogenesis or apoptosis and multiple angiogenic factors are needed for progression of neuroblastoma [19]. This evidence concerns the gene VEGFA and neuroblastoma.