Prinomastat, a synthetic inhibitor of MMPs, shows inhibition of tumor cell proliferation in human neuroblastoma SK-N-BE2 orthotopically xenotransplanted tumors in immunodeficient mice and prolonged survivability, suggesting that advanced stages of neuroblastoma show increased expression of both MMP-2 and MMP-9 [31]. The gene discussed is MMP9; the disease is neoplasm.