Treatment of neuroblastoma SH-SY5Y cell line with somatostatin causes anti-proliferative effect by inhibition of PDGF-induced PDGFR phosphorylation followed by Ras inactivation providing multiple regulatory role of PDGF in cell proliferation and angiogenesis in high risk neuroblastoma [24]. The gene discussed is PDGFRB; the disease is neuroblastoma.