Anti-c-Kit administration in 5 neuroblastoma cell lines IMR-5, SK-N-SH, SK-N-BE, AF8, and SJ-N-KP and the neuroepithelioma (NE) line CHP-100 showed significant decrease in cell viability due to induction of apoptosis suggesting that SCF is produced by some neuroblastoma cell lines via an autocrine loop to protect them from apoptosis and stimulate neuroblastoma growth and metastasis [29]. The gene discussed is KITLG; the disease is neuroblastoma.