Treatment of 3 neuroblastoma cell lines such as SK-N-AS, IMR-32, and SH-SY5Y with SU11657, which is a multiple inhibitor targeting PDGFR, VEGFR, and c-Kit, reduced their expression and tumor angiogenesis by 63–96% also signifying the crucial roles of these angiogenic ligands and their receptors in tumor cell proliferation and survival [23]. This evidence concerns the gene KDR and neoplasm.