KDR and neuroblastoma: Combinatorial treatment with vinblastine, a monoclonal antibody (DC101) targeting VEGFR-2 and rapamycin (mTOR inhibitor) in both neuroblastoma cells and orthotopic xenografted mice showed significant inhibition of tumor growth, angiogenesis, and reduction in microvessel formation suggesting that this combination may be relevant to design new curative strategies against neuroblastoma [57].