Argatroban (a derivative of arginine and a potent anti-coagulant and anti-thrombin agent) serves as a useful therapeutic tool for inhibition of thrombin-induced VEGF production in human neuroblastoma (NB-1) cells, and it may be effective in controlling disorders linked to thrombin-induced VEGF production in neuronal cells [58]. This evidence concerns the gene VEGFA and neuroblastoma.