High levels of expression of VEGF-A121, VEGF-A165, VEGF-B, VEGF-C, FGF-2, Ang-2, TGF-α, and PDGF-A have been documented in an analysis of 22 neuroblastoma cell lines and 37 tumor samples suggesting that multiple angiogenic growth factors interplay in the regulation of neovascularisation in advanced stage neuroblastoma [20]. The gene discussed is FGF2; the disease is neoplasm.