MYCN and neuroblastoma: Targeted inhibition of N-Myc by peptide nucleic acid (PNA) in human neuroblastoma N-Myc-amplified (GI-LI-N) and N-Myc-unamplified (GI-CA-N) cells showed cell cycle inhibition with induction of neuronal differentiation and apoptosis in N-Myc amplified cells and caused significant reduction in cell viability with N-Myc translation inhibition, accumulation of cells in G1, and induction of differentiation and apoptosis [42].