TIMP2 and neuroblastoma: Immunohistochemical analysis of the expression patterns of MMP-2, MMP-9, and their specific inhibitor, namely, tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) in 31 neuroblastoma patients revealed that increased expression of MMP-2 but not that of MMP-9 and decreased expression of TIMP-2 in stromal tissues of neuroblastoma had significant association with progression of advanced stage disease [30].