Retinoic acid reduces human neuroblastoma cell migration and invasiveness as evident from down regulation of expression of doublecortin (a microtubule-associated protein involved in neuronal migration) and lissencephaly-1 (another protein involved in neuronal migration) and upregulation of expression of neurofilament protein-68 in human neuroblastoma SK-N-SH cell line [64]. This evidence concerns the gene PAFAH1B1 and neuroblastoma.