EGF and neoplasm: The “angiogenic switch”, a rapid increase of blood vessel formation to support tumor growth, is triggered by (1) oncogene-mediated tumor expression of angiogenic proteins including VEGF, fibroblast growth factor (FGF), platelet derived growth factor (PDGF), endothelial growth factor (EGF), lysophosphatic acid (LPA), and angiopoietin (Ang), (2) metabolic and/or mechanical stress, (3) genetic mutations, (4) the immune response, and maybe most prominently (5) hypoxia.