Novel approaches to improve antiangiogenic therapy include strategies to target the angiopoietin-TIE system, Hif-1, endothelial-specific integrin/survival signaling (e.g., by cilengitide) as well as the use of vascular-disrupting agents (VDAs), which selectively disrupt already existing tumor vessels by targeting dysmorphic endothelial cells. Here, HIF1A is linked to neoplasm.