STAT1 and cancer: Moschos et al [33] observed a higher density of dendritic cells and T cells in melanomas of patients who exhibited clinical response to adjuvant high dose IFN-α therapy; the same group identified a higher expression of phosphorylated STAT1 tyr701 (pSTAT1) and higher pSTAT1/pSTAT3tyr705 in cancer cells of patients with tumors displaying this type of infiltrate and this was associated with longer overall survival [34].