Moreover, Kryczek et al [44] observed a combined infiltration of IL-17 expressing CD4+ T cells and CD8+ effector T cells; through synergistic action between IL-17 and IFN-γ expression, Th17 cells were observed to stimulate the expression of CXCL-9 and -10 by ovarian cancer cells as well as tumor infiltrating macrophages in order to recruit more effector T and NK cells to the tumor microenvironment. This evidence concerns the gene CD4 and neoplasm.