MAPT and Alzheimer disease: Because HSS-888 showed strong inhibition of Aβ aggregation and secretion, this extract was utilized in the present in vivo study using transgenic a transgenic mouse model for AD (Tg2576 mice) that over-express Aβ protein in order to determine the pathological response of Aβ aggregation and Tau phosphorylation when an optimized turmeric extract was consumed.