NFKB1 and pancreatic neoplasm: Recent studies have reported that apigenin functions as either a pro-apoptotic or anti-apoptotic mediator via suppression of NF-κB activation in malignant cells, such as in pancreatic cancer cells [32] and in various models of inflammation including T cell resistance to activation-induced cell death [33], lipopolysaccharide-stimulated monocytes and macrophages [34], and pancreatic beta-cells [35].