Here, "downs" as well as "ups" of the CD3+T-cells expressing CD25 can be clinically interpreted in four directions: 1) spontaneous variation without major clinical relevance (statistical regression); 2) "normalisation" (towards normal values); 3) "suppression" (CD25+T-cells interpreted as "helper cells"); 4) "stimulation" (CD25+T-cells as containing CD4+CD25+ T-cells that comprise regulatory T-cells, which suppress an effective immune response against tumours [115-117]). This evidence concerns the gene CD4 and neoplasm.