AGER and Hyperglycemia: Because the level of RAGE expression is regulated by the presence of its ligands, such as AGE, that are known to accumulate at a greater rate for a longer time in diabetic compared with non-diabetic patients, we hypothesized that the RAGE pathway may underlie the difference in the clinical effects of hyperglycemia as well as response to IIT between diabetic and non-diabetic patients admitted to ICU [19].