Figure 1 shows that the plasma sRAGE concentration is significantly higher and IL-6 lower when diabetic patients are compared with those without diabetes (median (IQR) 2,406 (1,534 to 3,613) vs. 1,302 (918 to 2,260 pg/ml); P = 0.003) and (61 (27 to 124) vs. 159 (59 to 224 pg/ml); P = 0.02), respectively. The gene discussed is IL6; the disease is diabetes mellitus.