THBD and diabetes mellitus: However, in patients with diabetes, IIT significantly decreases plasma sRAGE (903 (586 to 2,732) vs. 2,684 (1,956 to 4,312) pg/ml, P = 0.03) and thrombomodulin (61 (35 to 81) vs. 104 ng/ml, P = 0.03) at day 7 post-admission, while creatinine clearance did not significantly change over time (Figure 3).