Overweight and obesity are associated with a different secretion rate of several adipocytokines, such as reduced adiponectin [1] and increased retinol-binding protein 4 (RBP4) [2], adipocyte fatty acid binding protein (aFABP) [3], and visfatin [4]. This evidence concerns the gene RBP4 and obesity due to melanocortin 4 receptor deficiency.