The AKT2−/− mice exhibited a very different phenotype, reminiscent of mice with Type 2 diabetes mellitus, suggesting a specific role for this isoform in glucose metabolism [13] although more recent studies in AKT1−/− mice have indicated that both AKT1 and 2 are required for the regulation of glucose homeostasis in the periphery [14]. Here, AKT1 is linked to diabetes mellitus.