IFNG and infection: Furthermore, the activation of one member of the nuclear factor of activated T-cell (NFAT) family transcription factors NFATc1 mediated IFNγ production by macrophages and DC, developing an effective Th1 response and DC maturation during T. cruzi infection in double-knockout mice (Myd88−/− and Trif−/−), despite high sensitivity to the infection [44].