SELP and Venous thrombosis: In a recent study P-selectin was found in HIV-infected patients to be independently and most strongly associated with venous thrombosis.64 Stored in endothelial cells and platelet granules, P-selectin interacts with its receptor to promote a hypercoagulable environment by inducing the generation of prothrombotic microparticles from leukocytes and upregulation of tissue factor expression on monocytes.65 Prospective studies in HIV-uninfected participants with malignancies have demonstrated that P-selectin is significantly elevated in patients with an impending or acute VTE.