A subgroup analysis of patients with DM from this study showed that these patients benefited from a higher reduction in the primary end point (a composite of cardiovascular death, myocardial infarction, and stroke) than subjects without DM (hazard ratio—HR 0.72 versus 0.86, P < 0.001), particularly if on insulin therapy (HR 0.63, P = 0.009). The gene discussed is INS; the disease is diabetes mellitus.