HMGCR and Alzheimer disease: The primary findings of our study are that: (1) SNPs unequivocally associated with plasma cholesterol demonstrate a significant global association with AD risk, (2) rs3846662 and rs1532085 are associated with AD age-of-onset, (3) rs3846662 is associated with HMGCR exon 13 splicing in human liver in vivo and in brain and liver-derived cell lines in vitro.