Sp-regulated genes include several that are important for cancer cell proliferation [cyclin D1, epidermal growth factor receptor (EGFR), hepatocyte growth factor receptor (c-MET)], survival (bcl-2 and survivin), angiogenesis [vascular endothelial growth factor (VEGF) and its receptors (VEGFR1/R2) and pituitary tumor-transforming gene 1 (PTTG-1)], and inflammation (p65 subunit of NFκB) [23,29-38]. This evidence concerns the gene VEGFA and cancer.