SP4 and malignant colon neoplasm: We observed that BA decreased expression of Sp1, Sp3 and Sp4 proteins in both RKO and SW480 colon cancer cells and tumors (Figures 2A and 6C) and this was accompanied by parallel decreases in survivin and VEGF (Figures 2A and 2B), and these results are comparable to those observed in LNCaP prostate and KU7 bladder cancer cells treated with BA [20,32].