TLR4 and chronic atrophic gastritis: In a recent study TLR4 3725G>C polymorphism was indentified as a risk factor for severe gastric atrophy in H. pylori sero-positive Japanese subjects with OR of 1.43 and 1.47 for G/C and C/C genotypes, respectively [26], however in the same study this polymorphism was not associated with the risk for GC.