TP53 and Reoviridae infectious disease: Our data showed that there was no significant difference between the HCT116 p53+/+ and p53−/− cells in reovirus production within at least the first round of reovirus infection (18 hpi; Figure 1A) and the level of apoptosis induced by reovirus was not significantly different between p53+/+ and p53−/− HCT116 cells or between A549 control and p53 knockdown cells (Figure 3A and B).