TP53 and Reoviridae infectious disease: Moreover, inhibition of NF-κB activation by treatment of NF-κB inhibitor was shown to suppress the upregulation of p53 target genes with the treatment of reovirus and Nutlin-3a, further confirming the link between the enhancement of NF-κB activation and the increase in cytotoxicity induced by the combination of p53 accumulation and reovirus infection.