Stepwise increases in the prevalence of a history of hypertension, cerebrovascular disease, and congestive heart failure, pulse pressure, uric acid, phosphorous, calcium-phosphorous product, proteinuria, and percentage of non-ACEI/ARB antihypertensive drug use and stepwise decreases in the diastolic blood pressure, albumin, hemoglobin, eGFR, and calcium corresponded to advancement in CKD from stage 3 to 5. The gene discussed is ALB; the disease is cerebrovascular disorder.