NFKB1 and central nervous system cancer: In addition, several studies have indicated that curcumin can induce the antiproliferative, apoptotic, radiosensibilizing and chemosensibilizing effects on glioma cells via the up-regulation of p53, p21WAF1 and the inhibitor of growth 4 (ING4), inhibition of NF-κB and AP-1 transcriptional activities and stimulation of the caspase cascade [132-135,138-140].