AR and Familial prostate cancer: More specifically, curcumin may mediate growth inhibitory and apoptotic effects in AD and AI prostate cancer cells by down-regulating the expression and/or activity of diverse oncogenic and survival signaling components, including EGFR, erbB2, hedgehog, androgen receptor (AR) and PI3K/Akt, NF-κB, Bcl-2, Bcl-xL and TMPRSS2-ERG fusion protein (Figures 1 and 2) [107,108].