It has also been shown that curcumin or resveratrol, alone or in combination, induced the growth inhibitory and apoptotic effects on PTEN-CaP8 prostate cancer cells derived from PTEN-knockout mice model of PC by the down-regulation of the expression levels of pAkt, cyclin D1, the mammalian target of rapamycin (mTOR) and AR proteins [89]. This evidence concerns the gene PTEN and pachyonychia congenita.