It has been noticed that a combination of low doses of curcumin plus tamoxifen resulted in a synergistic induction of apoptosis and autophagy in chemoresistant melanoma cells and the silencing of multidrug resistance transporter ABCA1 in highly tumorigenic and metastatic human M14 melanoma cells, which are resistant to curcumin treatment, restored their sensibility to curcumin [122,123]. The gene discussed is ABCA1; the disease is melanoma.