NFKB1 and Familial prostate cancer: For instance, it has been shown that the curcumin encapsulation in biodegradable and biocompatible poly(lactic-co-glycolic acid) (PLGA) nanospheres resulted in an enhanced intracellular uptake of curcumin-loaded polymeric nanospheres and improved cytotoxic effects of curcumin on metastatic LNCaP, PC3 and DU145 prostate cancer cell lines in vitro relative to free curcumin, via the inhibition of NF-κB activity [24,91,94].