ESR1 and breast cancer: PCA also displayed higher efficiency than curcumin at inducing apoptosis on ER-α negative-MDA-MB-231 breast cancer cells and antitumoral effect on MDA-MB-231 cell xenografts in vivo by inhibiting p21WAP1, survivin and NF-κB and its downstream effectors, including cyclin D1 and Bcl-2, and activating caspase cascade [210].