For instance, the systemic administration of gemcitabine plus polymeric micelle-encapsulated curcumin formulation displaying higher bioavailability in plasma and tissues as compared to free curcumin, induced greater tumor growth inhibitory and antimetastatic effects than curcumin on pancreatic cancer cells subcutaneously or orthotopically implanted in nude mice via an inhibition of NF-kB and its targeted genes [101]. This evidence concerns the gene NFKB1 and familial pancreatic carcinoma.