AKT1 and Alzheimer disease: For instance, it has been reported that curcumin inhibited the growth and triggered the apoptosis of AD LNCaP and AI PC3 cells in vitro by down-regulating the expression levels and intrinsic activities of EGFR and its downstream signaling elements, including PI3K/Akt and NF-κB (Figures 1 and 2) [141,142].