Especially, these novel curcumin formulations could be used to simultaneously target different tumorigenic cascades initiated by different growth factors such as EGFR family members, hedgehog, Wnt/β-catenin and their downstream signaling elements such as PI3K/Akt and NF-κB as well as multidrug resistance transporters that may cooperate for the acquisition of an aggressive behavior by cancer cells during disease progression, treatment resistance and disease relapse. Here, AKT1 is linked to cancer.