Of clinical interest, curcumin has also been observed to sensitize glioma cells to radiation and several current chemotherapeutic drugs, including cisplatin, etoposide, camptothecin and doxorubicin through a reduced expression of Bcl-2 and the inhibitor of apoptosis proteins (IAPs) as well as DNA repair enzymes such as O6-methylguanine-DNA methyltransferase (MGMT), DNA-dependent protein kinase, Ku70, Ku80 and excision repair cross-complementing rodent repair deficiency, complementation group 1 (ERCC-1) [133]. Here, MGMT is linked to hyperinsulinemic hypoglycemia, familial, 4.