AKT1 and prostate carcinoma: For instance, a treatment of 8-week old TRAMP mice with a diet supplemented with 2% curcumin or 0.05% β-phenyethylisothiocyanate (PEITC), or a combination of 1% curcumin plus 0.025% PEITC for a period of 10 or 16 weeks significantly inhibited the incidence of the formation of high-grade prostatic intraepithelial neoplasias and prostate cancer development, at least in part, by down-regulating the Akt pathway [51,52].