NFKB1 and cancer: Especially, these novel curcumin formulations could be used to simultaneously target different tumorigenic cascades initiated by different growth factors such as EGFR family members, hedgehog, Wnt/β-catenin and their downstream signaling elements such as PI3K/Akt and NF-κB as well as multidrug resistance transporters that may cooperate for the acquisition of an aggressive behavior by cancer cells during disease progression, treatment resistance and disease relapse.