A combination of CDF plus gemcitabine also induced greater tumor growth inhibitory effects on MiaPaCa-2-derived subcutaneous xenografts in severe combined immunodeficient (SCID) mice than curcumin plus gemcitabine through the down-regulation of the NF-κB activity, COX-2 and miR-21 expression and increased expression of phosphatase tensin homolog deleted on chromosome 10 (PTEN) and miR-200 expression [216]. This evidence concerns the gene NFKB1 and neoplasm.