Importantly, the results from in vivo studies consisting of the intraperitoneal injection of curcumin at doses of 50 and 100 mg/kg every 2 days, respectively have also indicated that this dietary compound inhibited the tumor growth and spontaneous metastasis of B16BL6 melanoma cells in mice at least in part by down-regulating the expression at the transcriptional level of an oncogenic product, phosphatase of regenerating liver-3 (PRL-3) [34]. The gene discussed is PTP4A3; the disease is melanoma.