The chemosensibilizing effects of curcumin were mediated at least in part via the inhibition of STAT-3 and NF-kB-regulated gene products such as cyclin D1, c-Myc, Bcl-2, Bcl-xL, cellular IAP-1, COX-2, MMPs and VEGF in pancreatic cancer cells (Figures 1 and 2) [27,154]. The gene discussed is PTGS2; the disease is familial pancreatic carcinoma.