Curcumin can also cause DNA damage and apoptotic/necrotic death of prostate cancer cells by up-regulating diverse pro-apoptotic factors such as the p53 tumor suppressor protein, Bax, Bak, Noxa, p53 up-regulated modulator of apoptosis (PUMA) and/or BCL-2-like 11 (Bim) [107,108]. This evidence concerns the gene TP53 and Familial prostate cancer.