More specifically, curcumin induced the anti-proliferative, anti-migratory and apoptotic effects on medulloblastoma cells via the down-regulation of the expression levels of the SHH ligand and the GLI-1 transcriptional effector of the hedgehog cascade, β-catenin, the phosphorylated forms of Akt and NF-κB as well as their downstream targets such as c-Myc, N-Myc, cyclin D1 and anti-apoptotic factors Bcl-2 and Bcl-xL (Figures 1 and 2) [129,130]. This evidence concerns the gene SHH and medulloblastoma.