BRAF and melanoma: Moreover, curcumin induced antiproliferative and apoptotic effects on human A375, C32, G-361 and WM 266 melanoma cell lines, all of which have B-Raf mutations, B16-R melanoma cells resistant to doxorubicin and novel mouse melanoma cells, whereas curcumin induced no cytotoxic effect on normal melanocytes [33,119-122].