Moreover, the treatment of HCT-116 or HT-29 colon cancer cells with 5-fluorouracil and oxaliplatin also resulted in an enrichment of cancer cells with stem cell-like phenotypes as evidenced by an increased proportion of cancer cell fractions expressing high levels of CD133, CD44, CD166 and/or EGFR levels [60]. This evidence concerns the gene ALCAM and malignant colon neoplasm.