CD44 and cancer: By contrast, curcumin, alone or in combination with 5-fluorouracil and oxaliplatin, induced a marked reduction in cancer stem cell-like cells, as indicated by a decrease in the expression levels of CD133, CD44, CD166 and EGFR as well as their ability to impair the colonosphere formation in vitro of chemosurviving HCT-116 or HT-29 colon cancer cells [60].