MCL1 and ovarian cancer: Similarly, a PLGA nanoparticle formulation of curcumin conjugated with a monoclonal antibody specific for ovarian cancer cells also sensibilized the cisplatin-resistant A2780CP ovarian cancer cells to the anti-proliferative and cytotoxic effects induced by cisplatin or radiation via the down-regulation of the expression of β-catenin, Bcl-xL and Mcl-1 pro-survival proteins [95].