PTGS2 and familial pancreatic carcinoma: Of particular interest, it has also been observed that a combination of low doses of curcumin and other dietary agents (isoflavone, resveratrol and epigallocatechin-3-galate), COX-2 inhibitor (celecoxib) or an omega-3 fatty acid (docosahexaenoic acid) induced synergistic growth inhibitory and apoptotic effects on pancreatic cancer cells in vitro and in vivo [160-162].