For instance, curcumin inhibited the proliferation of Panc28 and L3.6pL pancreatic cancer cells in vitro by down-regulating NF-kB-dependent gene transactivation and Sp1, Sp2 and Sp3 transcription factors, which are overexpressed in pancreatic cancers [153]. This evidence concerns the gene SP3 and familial pancreatic carcinoma.