In a study done by Anbazhagan et al. [4] ACE-DD genotype showed a higher level of systolic pressure with a median of 166 mmHg (P < 0.05) when compared to II and ID genotypes and two heterozygous conditions of NPHS2-R229Q polymorphism were found among 105 CKD patients. Here, NPHS2 is linked to chronic kidney disease.