CD8A and disease arising from reactivation of latent virus: In this context, the proliferation of activated cytotoxic CD8+ T cells could be due to the inhibition of IL-2 expression by AlHV-1 latent infection of CD8+ T cells leading either to the loss of autocrine "self-control" of T cell proliferation or to an indirect inhibition of regulatory T cells (Treg) homeostasis [35,36].