TGFB1 and neoplasm: A recently introduced strategy to increase the therapeutic efficacy of tumor vaccination is to combine different immunological approaches, i) applying multifaceted antigen vaccines to target a broad spectrum of tumor antigens, ii) providing co-stimulation, iii) reducing or eliminating suppressive immune cells, e.g. Tregs [7], and iv) blocking tumor-induced immune suppression mediated by e.g. TGF-β [19].