Our results indicated that the starved cells pre-treated with curcumin (0–20 μM) and then stimulated with 20 ng/ml EGF for 3 h showing the concentration-dependently reduced phospho-EGFR protein levels in these NSCLC cell lines; interestingly, the endogenous EGFR were also dramatically depleted (Figure 1C). The gene discussed is EGF; the disease is non-small cell lung carcinoma.