CD4 and colorectal cancer: Recent results of T cell immunomonitoring of ovarian and colorectal cancer patients vaccinated with p53 overlapping peptides showed strong induction of p53-specific CD4+ T cell responses, that were even detectable by ex vivo analyses of peripheral blood mononuclear cells (PBMCs) after vaccination without inducing any detectable p53-specific CD8+ T cells [23], [24].