SIRT1 and liver dysplastic nodule: Although we were unable to detect a significant change in Sirt1 in the tubulointerstitial compartment of DN, others have reported that the expression of another member of the sirtuin family, Sirt3 is suppressed in cultured renal tubular epithelial cells by angiotensin II, a key mediator of the pathophysiology of diabetic renal disease [46].