As shown in Fig. 5B and C, HCV core antigen concentration was negatively correlate (r = −0.2847, P = 0.0083) with CD4+ T cell counts, while no correlation was found between HCV viral load and CD4+ T cell counts in HIV-coinfected CHC patients, though the concentration of serum HCV core antigen was highly correlated with HCV RNA level in both HCV mono-infected and HCV/HIV-1 co-infected individuals as described above. This evidence concerns the gene CD4 and cryohydrocytosis.