When separated on ER status (Figure 3A and 3B) the 19 CNI model significantly improved prognostication when compared with the clinical plus tumor subtypes: ER+ (C-Index  =  0.72 vs. 0.62, p<0.0001) and ER– (C-Index  =  0.78 vs. 0.63, p = 0.001). Here, ESR1 is linked to neoplasm.