Furthermore, transient restoration of wild type VDR expression in VDR-negative human SW620 colon cancer cells decreases nuclear β-catenin level, whereas VDR-ΔAF2, VDR-L417S or VDR-E420Q mutants, unable to bind classical coactivators and activate gene transcription [21], did not. The gene discussed is VDR; the disease is colonic neoplasm.