GSK3B and malignant colon neoplasm: Another mechanism of Wnt/β-catenin inhibition in colon cancer has been proposed by Kaler and cols.: 1,25(OH)2D3 decreases the synthesis and secretion by THP-1 macrophages of interleukin-1β, a cytokine that activates the Wnt/β-catenin pathway in colon cancer cells through the blockade of β-catenin phosphorylation by GSK-3β [37].