This heterogeneity may explain why a statistically significant increase in nuclear β-catenin level was found in ACF of Apcmin/+Vdr-/- as compared to Apcmin/+Vdr+/+ or Apcmin/+Vdr+/− mice (Figure 2c), but only a minor trend was observed in adenomas and carcinomas (Figure 2d). This evidence concerns the gene VDR and adenoma.