Moreover, 7 female-biased genes (ABCA1, APOA4, APOA5, APOC4, DOCK7, HNF4A, LDLR) and 3 male-biased genes (ANGPTL4, LIPC, PSRC1) are adjacent to a subset of the 30 loci previously associated with circulating concentrations of low density lipoprotein (LDL)-cholesterol, high density lipoprotein (HDL)-cholesterol and triglycerides and polygenic dyslipidemia by GWAS analysis [43], [44], with enrichment p-values ranging from 3E-9 to 5E-6 (Figure 3A, Table S2F and Table S3B). The gene discussed is ANGPTL4; the disease is metabolic syndrome.