Specifically for pneumococcal bacteremia 15 tagSNPs in eight genes (CD46, SFTPA1, SFTPD, ILIR1, IL4, IL12B, IL18, and MYD88) and seven tagSNPs in seven genes (MBL2, SFTPD, IL1B, ILIR1, IL4, and PTAFR) are associated with cases of pneumococal bacteremia compared to controls in EA and AA, respectively (Table S3). This evidence concerns the gene IL4 and bacterial infectious disease with sepsis.