Analysis of CHRNA5 promoter haplotypes in human BE(2)-C neuroblastoma cells indicated that the “mixed” haplotype containing the rs3841324-[Δ]:rs503464-[T] variations (pGL4(XfNNA5dTTC) or pGL4(NNA5dTTC)) showed decreased (1.6–2.0-fold) relative firefly luciferase activity compared to either the “protective” haplotype containing the rs3841324-[N]:rs503464-[A] variations (i.e. pGL4(XNNA5iATC) or pGL4(NNA5iATC)) or the “risk” haplotype containing the rs3841324-[N]:rs503464-[T] variations (i.e. pGL4(XNNA5iTGG)) (Figure 2). Here, CHRNA5 is linked to neuroblastoma.