We studied global methylation of LINE1 and the following genes: CDKN2B (p15INK4b), PGRA, PGRB, OLIG2, NOR1, CDH13, MAPK15, miR-124a-1, and miR-124a-3 by bisulfite pyrosequencing in 12–20 MDS patient samples. The gene discussed is MAPK15; the disease is myelodysplastic syndrome.