HSPD1 and tuberculosis: Several of the DNA vaccine candidates, when used in homologous prime boost regimen have exhibited a considerable potential in mouse model of tuberculosis, such as, those expressing Ag85A (mycolyl transferase) [21], ESAT-6 [14], PstS-1, PstS-3 [22] and hsp65 [23], however, the protection conferred by these vaccines was generally lower and rarely equal to BCG [24], [25].