On the other hand, the cells exposed to simulated hypophosphatemia (0.5 mM) showed significantly decreased level of eNOS, but significantly increased levels of CDK2, Akt, p-Akt, p-Mek, p38, p-p38, p53, PP2A, Stat1, p-PLCg2, and PKCβ2, and increased Bcl-xl/Bax ratio. Here, NOS3 is linked to hypophosphatemia.