Although quercetin has been shown to inhibit TNF-induced expression of the proinflammatory genes IP-10 and MIP-2 by targeting the NF-κB signaling pathway and modulating H3 acetylation in murine small intestinal epithelial cells [6], the excise molecular mechanisms by which quercetin inhibits expression of the specific proinflammatory gene such as COX-2 in human cancer cells remained unclear. The gene discussed is PTGS2; the disease is cancer.