WNT5A and Alzheimer disease: We observed that (1) Wnt5a/CaMKII signaling is up-regulated at the early stages of AD development in an APPswe/PSEN1ΔE9 transgenic mouse model, (2) Aβ activates Wnt5a signaling in primary cortical cultures, (3) Aβ-induced Wnt5a up-regulation is a critical molecular step leading to the development of Aβ neurotoxicity in cultures, (4) Wnt5a stimulates inflammatory processes, and (5) Wnt5a is critical for Aβ-induced inflammatory response.