By setting the p value at ≤0.05, we found significant downregulation of 39 signaling pathways, including some tumor-related pathways such as the cell cycle pathway, Wnt signaling pathway, vascular endothelial growth factor (VEGF) signaling pathway, and transforming growth factor (TGF-β) signaling pathway. This evidence concerns the gene TGFB1 and neoplasm.