It should be noted that the expression of many genes regulated by NF-κB showed altered expression in the DMH + Calcium group, e.g., TNF, PTGS2, MYC, CCND1, ETS-related gene 1 (ERG1), S100A9, and lymphoid enhancer factor 1 (LEF1), suggesting that NF-κB may also serve as a hub gene in the calcium-mediated prevention of CRC. This evidence concerns the gene LEF1 and colorectal carcinoma.