One study rigorously evaluated the predictive utility of other novel risk markers such as CRP, excluding NT-proBNP, and indicated that they offer minimal improvement over the Framingham Risk Score [20]; however, another suggested that hs-CRP, combined with NT-proBNP, troponin I, and cystatin C, is associated with CHD when the influence of age is excluded, and in niche populations [21]. Here, NPPB is linked to coronary artery disorder.