Furthermore, in our study, the mean levels of NT-proBNP in the middle and top tertiles were greater than the cut-off point (78.9 pg/mL) for diagnosis of angiographic CHD (Table 2), indicating the severity of CHD increased gradually in tertile groups, as well as from the control to the pre-diabetic and diabetic groups. The gene discussed is NPPB; the disease is coronary artery disorder.