Using these cut-off points, NT-proBNP showed higher sensitivity, specificity, positive and negative predictive values with a greater area under the ROC curve than other biomarkers, except for the specificity and positive predictive value of troponin T. By combining the four biomarkers we obtained a slightly greater area under the ROC curve and higher positive predictive value for CHD, using the ROC curves and Youden index, (Table 2). Here, NPPB is linked to coronary artery disorder.