TLR4 and head and neck squamous cell carcinoma: In the present primary HNSCC cohort, 125 patients (90.6%) showed a homozygous TLR4 genotype for aspartate at aminoacid location 299, and 13 patients (9.4%) had a TLR4 Asp299Gly variant (minor allele frequency (MAF) ~4.7%).