Our study provides evidence for an established concept of altered chemosensitivity of tumor cells to chemotherapeutic drugs in regards to their respective polymorphic genotype [32] as we demonstrate that patients with TLR4 Asp299 wild-type genotype showed significantly better DFS with adjuvant systemic therapy including agents like cisplatin and 5-fluoruracil. The gene discussed is TLR4; the disease is neoplasm.