Significant decreases in AD brain were observed for BDNF (31%; p < 0.01), Bcl-2 (23%; p < 0.05), BIRC3 (44% p < 0.01) and BIRC4 (32%; p < 0.01) when compared to age-matched controls (Figure 5). This evidence concerns the gene BIRC3 and Alzheimer disease.