FLT1 and neoplasm: In the present study, we aimed to analyze the potential prognostic and predictive influence of VEGFR-1/2 and TKTL1 expression on early response parameters such as pathological tumour regression grading (TRG) and tumour downstaging and on 3-year disease-free survival in patients with LARC undergoing cetuximab-based chemoradiotherapy within clinical trials.