FLT1 and neoplasm: Normalised VEGFR-1/-2 expression of patients with LARC was significantly higher in pre-treatment tumour tissue in comparison to the corresponding normal mucosa (VEGFR-1; p = 0.0023 and VEGFR-2; p = 0.0005) but failed to be statistically significant for TKTL1 (p = 0.082).