Plasma tissue inhibitor of metalloproteinases-1 (TIMP-1) has been suggested for early detection of CRC [59-61], as high plasma TIMP-1 levels were shown to identify colon cancer (CC) patients with a sensitivity of 63% at 98% specificity, patients with early CC (stage I and II) with a sensitivity of 56% at 98% specificity and patients with right-sided CC with a sensitivity of 72% at 98% specificity [61]. This evidence concerns the gene TIMP1 and malignant colon neoplasm.