TPO and Thrombocytopenia: As WT Lnk R8 may have a general effect on cytokine-dependent hematopoiesis (TPO-induced megakaryopoiesis) not restricted to leukemic cell growth, thus, it should be cautioned that WT Lnk R8 treatment could carry risk such as thrombocytopenia although further studies are needed to elucidate this.