DYSF and muscular dystrophy: The additional burden of lifelong muscular dystrophy may increase frequency and accelerate oncogenesis, as speculated by Chamberlain et al.[15] but this is not supported by the failure to detect RSC development in the SJL/J strain, a non-related, Group 2 strain [21] with a dysferlin splice site mutation that removes part of the C2E domain [20].