CDKN1C and neoplasm: In contrast, ERSCs generally have a loss of heterozygosity (LOH) at the 11p15 region, resulting in increased expression of several imprinted genes such as H19, IGF2, and p57KIP2[29], [30], loss of skeletal muscle expression of the normally highly expressed gene GOK[31], and potentially the loss of a tumor suppression gene located in the region [32].