Many of the genes identified code for components of key signaling pathways, such as the Wnt, Hedgehog and RTK pathways, for instance FGF9, PTCH1, GLI2, GLI3 and TCF7L1. Using the identification of FGF9 as a lead, we found that FGFR signals play roles in loss of colon cancer cell adhesion and induction of cell motility. Here, TCF7L1 is linked to malignant colon neoplasm.