The inferred network contains central signal transducers of motility signals such as ERK1/2 and PTK2 (focal adhesion kinase), and converges on the transcription factors JUN/JUNB and FOSL1. Importantly, FOSL1 has previously been identified as a key transcription factor in the control of tumor cell motility [39]. The gene discussed is MAPK3; the disease is neoplasm.