Key steps in developmental and tumor-associated EMT are loss of E-Cadherin-based cell adhesion (by epigenetic silencing or transcriptional repression of CDH1, coding for E-Cadherin), reorganisation of the cytoskeleton leading to altered cell morphology, and induction of mesenchymal-specific gene expression, such as activation of FN1 and VIM[6], [7], [8], [9], [10], [11]. This evidence concerns the gene CDH1 and neoplasm.