Even if we may not directly extrapolate our experimental data obtained in mice to human health, it is interesting to note, in accordance with our experimental data, that human biopsies of non-alcoholic fatty liver disease patients are characterized by an increased expression of SREBP1c and decreased expression of PPARα and this was associated with n-3 PUFA depletion [54]. This evidence concerns the gene SREBF1 and metabolic dysfunction-associated steatotic liver disease.