However, when we used the VEGFR-2 shRNA to silence the expression of VEGFR-2 in ovarian and hepatocellular cancer cells, the cell viability was decreased to some extent, demonstrating that the VEGFR-2 signaling participates in the regulation of cancer cell proliferation, and the antiproliferation effect of hSulf-1 on cancer cells is partly due to the inhibition of VEGFR-2 signaling. The gene discussed is KDR; the disease is cancer.