Among 26 cases of hepatocellular carcinoma, there is an obvious decrease of p-VEGFR2Tyr1175 level in the hSulf-1-positive hepatocellular carcinoma than that in the hSulf-1-negative hepatocellular carcinoma (P<0.05), but no difference of t-VEGFR2 expression between them (P>0.05). This evidence concerns the gene KDR and hepatocellular carcinoma.