As the hSulf-1 gene exerts a wide role in regulating multiple pathways by inhibiting the phosphorylation of intracellular tyrosine kinases which could be critical in tumor cell proliferation and tumor angiogenesis, we therefore examined the expression of downstream proteins, including VEGFR-2 and serine/threonine kinase (AKT) in xenograft tumors. The gene discussed is KDR; the disease is neoplasm.