BCR and chronic myelogenous leukemia, BCR-ABL1 positive: To examine the role of hypoxia using immune competent mice, we made use of a syngenic model of blastic phase chronic myelogenous leukemia (CML) whereby C57Bl6/J mice were injected with murine bone marrow cells expressing the BCR-ABL and Nup98 translocation products, and green fluorescent protein GFP [30].