HIF1A and neoplasm: While HIF-1α expression is frequently promoted in normoxic tumor cells, for example through oncogenic stimuli, generating molecular signatures resembling hypoxic response in the absence of hypoxia (coined as “pseudohypoxia” [37]–[39]), hypoxic marker Pimonidazole can only be metabolized and form intracellular adducts at low oxygen concentrations, thus reflecting true hypoxia as opposed to pseudohypoxia.